INTRODUCTION TO HERPES VIRUS
⇒ HERPES VIRUS is the family of viruses, contains hundreds of viruses, maximum of which infects humans.
⇒ They are characterized by their ability to establish latent infections, enabling the virus to persist indefinitely within the hosts and to undergo periodic reactivation.
MORPHOLOGY OF HERPES VIRUS
⇒ Herpes virus is spherical & enveloped virus containing icosahedral capsid.
⇒ The capsid is composed of 162 capsomers & envelope carries surface glycoprotein spikes.
⇒ Size: 100-200 nm in diameter.
⇒ Genetic Material:- Linear dsDNA.
RESISTANCE SHOWN BY HERPES VIRUS
⇒ Herpes viruses are susceptible to fat solvents like Alcohol, Ether, Chloroform and Bile Salts.
⇒ They are heat labile and must be stored at -70°C
CLASSIFICATION OF HERPES VIRUS
There are about Eight different types of Herpes viruses known whose primary hosts are humans. They have been officially designated ‘Human Herpes virus types 1-8’ but their common names continue to be in general use, except for 6 & 7. These viruses are as follows: –
OFFICIAL NAME Common Name
Human Herpes virus type 1 Herpes Simplex virus type 1
Human Herpes virus type 2 Herpes Simplex virus type 2
Human Herpes virus type 3 Varicella – Zoster virus
Human Herpes virus type 4 Epstein – Barr virus
Human Herpes virus type 5 Cytomegalovirus
Human Herpes virus type 6 –
Human Herpes virus type 7 –
Human Herpes virus type 8 Kaposi’s Sarcoma-Associated Herpes virus
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VARICELLA – ZOSTER VIRUS (VZV) – INTRODUCTION, INFECTIONS, PATHOGENESIS, CLINICAL FEATURES, TREATMENT & PROPHYLAXIS
CYTOMEGALOVIRUS (CMV) – INFECTIONS, PATHOGENESIS, CLINICAL FEATURES, LABORATORY DIAGNOSIS, TREATMENT & PROPHYLAXIS